Cerebellar learning mechanisms
نویسندگان
چکیده
منابع مشابه
Mechanisms of cerebellar learning suggested by eyelid conditioning.
Classical eyelid conditioning has been used to great advantage in demonstrating that the cerebellum helps to improve movements through experience, and in identifying the underlying mechanisms. Results from recent studies support the hypotheses that learning occurs in both the cerebellar nucleus and cortex, and that these sites make different contributions. Specifically, results indicate that th...
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Since Marr's groundbreaking theory on the cerebellar cortex (Marr, 1969), the issue of cerebellar learning has been actively if not harmoniously investigated. Marr's theory was based on the equally seminal work of Eccles, Ito, and Szenthagotai (1967), which laid the foundations for providing a nearly complete circuit diagram of the cerebellum. The nearly 40 years of cerebellar research since ha...
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The cerebellum aids the learning and execution of fast coordinated movements, with acquired information being stored by plasticity of parallel fibre–Purkinje cell synapses. According to the current consensus, erroneously active parallel fibre synapses are depressed by complex spikes arising as climbing fibres signal movement errors. However, this theory cannot solve the credit assignment proble...
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In the adult brain, different neuronal populations display different degrees of plasticity. Here, we describe the highly different plastic properties of inferior olivary neurones and Purkinje cells. Olivary neurones show a basal expression of growth-associated proteins, such as GAP-43 and Krox24/EGR-1, and remarkable remodelling capabilities of their terminal arbour. They also regenerate their ...
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complement component expression and activation in the hippocampi of patients with multiple sclerosis corroborated this notion (Michailidou et al., 2015). In accordance with the findings of Jürgens and co-workers, synaptic density was decreased in demyelinated but also in myelinated hippocampi compared to control brains. Additionally, the complement components C1q and the C3 activation products ...
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ژورنال
عنوان ژورنال: Brain Research
سال: 2015
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2014.09.062